![]() We also thank the staff of the Clinical Trial Center, Zhongnan Hospital of Wuhan University for their guidance and supervision. We thank all the medical staff of the Department of Thyroid and Breast Surgery, Zhongnan Hospital of Wuhan University for their cooperation. Jonczyk MM, Jean J, Graham R, Chatterjee A. ![]() Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. Earlier ROM training was more conducive to restoring shoulder function, while earlier PRT had a synergistic effect on shoulder function recovery, but the improvement in QOL was more Referencesīray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. In summary, in breast cancer patients who underwent ALND, beginning ROM training 3 days after surgery or PRT 3 weeks after surgery under the supervision and guidance of a physiotherapist can lead to superior shoulder function improvement after BC surgery and faster QOL improvement according to systematic assessment. Although webcam-based home exercise has been proved to be effective, 50 the implementation of home training programs maybe inevitably insufficient that the therapist cannot guide each training session by the patient's side throughout the entire treatment process. Data on ROM also did not be collected at follow-up period. ![]() The trial also had some limitations in that the periods of treatment and follow-up time were long, and part of the treatment period was performed via home exercise. Patients who received SLNB had significantly higher CMS scores than patients after ALND, 31 Study Limitations The reason we chose CMS as the primary outcome was that reflect comprehensive function of shoulder including pain, ADL, strength, and mobility, which was widespread acceptance for usage of clinical studies with high reliability and validity 36. In our study, the shoulder function and related QOL of all participants showed a trend of gradual improvement in the process of receiving rehabilitation treatment. ![]() When each group reached n=50 participants completed all treatment and follow-up, the recruitment of new participants was terminated and the rest participants would still receive designated treatments according to Discussion Thus, before all the data collection was completed, we recruited more than 50 participants in each group. We continued recruiting until 50 participants in each group had completed all treatment and follow-up. Trial recruitment started on 31 August 2018 and ended on 31 December 2019. Patients with BC meeting the inclusion and exclusion criteria were included in this trial, and randomly allocated into four groups (group A, B, C, and D) according to a Flow of participants through the study A single center, prospective, randomized controlled trial was conducted with participants recruited at the department of thyroid and breast surgery of Zhongnan Hospital of Wuhan University between September 2018 and December 2019, with a 12-week supervised intervention and 6-week home-exercise period concluding in May 2020. ![]()
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